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Article

Non-coding landscapes of colorectal cancer.

World journal of gastroenterology - 7 Nov 2015

Ragusa Marco, Barbagallo Cristina, Statello Luisa, Condorelli Angelo Giuseppe, Battaglia Rosalia, Tamburello Lucia, Barbagallo Davide, Di Pietro Cinzia, Purrello Michele

Abstract excerpt

For two decades Vogelstein's model has been the paradigm for describing the sequence of molecular changes within protein-coding genes that would lead to overt colorectal cancer (CRC). This model is now too simplistic in the light of recent studies, which have shown that our genome is pervasively transcribed in RNAs other than mRNAs, denominated non-coding RNAs (ncRNAs). The discovery that mutations in genes...

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Identifiers

PMID: 26556998
DOI: 10.3748/wjg.v21.i41.11709
PMCID: PMC4631972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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