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Article

Pallidal neuronal apolipoprotein E in pantothenate kinase-associated neurodegeneration recapitulates ischemic injury to the globus pallidus.

Molecular genetics and metabolism - 1 Dec 2015

Woltjer Randall L, Reese Lindsay C, Richardson Brian E, Tran Huong, Green Sarah, Pham Thao, Chalupsky Megan, Gabriel Isabella, Light Tyler, Sanford Lynn, Jeong Suh Young, Hamada Jeffrey, Schwanemann Leila K, Rogers Caleb, Gregory Allison, Hogarth Penelope, Hayflick Susan J

Abstract excerpt

Pantothenate kinase-associated neurodegeneration (PKAN) is a progressive movement disorder that is due to mutations in PANK2. Pathologically, it is a member of a class of diseases known as neurodegeneration with brain iron accumulation (NBIA) and features increased tissue iron and ubiquitinated proteinaceous aggregates in the globus pallidus. We have previously determined that these aggregates represent condensed...

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Source

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Identifiers

PMID: 26547561
DOI: 10.1016/j.ymgme.2015.10.012
PMCID: PMC4688119

Genes

APOE
PANK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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