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Article

Wide expression of ZEB1 in sarcomatous component of spindle cell carcinoma of the esophagus.

Pathology international - 1 Dec 2015

Nakazawa Takuro, Nobusawa Sumihito, Ikota Hayato, Kuwano Hiroyuki, Takeyoshi Izumi, Yokoo Hideaki

Abstract excerpt

The pathogenesis of sarcomatous component in spindle cell carcinoma (SpCC) of the esophagus is unclear. To investigate the involvement of epithelial-mesenchymal transition (EMT) in sarcomatous differentiation, we performed immunohistochemistry for Slug, Twist, ZEB1, and ZEB2, transcription factors associated with EMT and E-cadherin, in 14 cases of SpCC of the esophagus. In order to verify the neoplastic nature of...

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Source

Identifiers

PMID: 26515382
DOI: 10.1111/pin.12354

Genes

ZEB1
ZEB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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