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Article

OVO-like 1 regulates progenitor cell fate in human trophoblast development

26 Oct 2015

Abstract excerpt

Epithelial barrier integrity is dependent on progenitor cells that either divide to replenish themselves or differentiate into a specialized epithelium. This paradigm exists in human placenta, where cytotrophoblast cells either propagate or undergo a unique differentiation program: fusion into an overlying syncytiotrophoblast. Syncytiotrophoblast is the primary barrier regulating the exchange of nutrients and...

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PMID: 26504231
DOI: 10.1073/pnas.1507397112

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