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Article

Protective alleles and modifier variants in human health and disease.

Nature reviews. Genetics - 1 Dec 2015

Harper Andrew R, Nayee Shalini, Topol Eric J

Abstract excerpt

The combination of next-generation sequencing technologies and high-throughput genotyping platforms has revolutionized the pursuit of genetic variants that contribute towards disease. Furthermore, these technologies have provided invaluable insight into the genetic factors that prevent individuals from developing disease. Exploiting the evolutionary mechanisms that were designed by nature to help prevent disease...

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PMID: 26503796
DOI: 10.1038/nrg4017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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