Article
Moderate Sustained Virologic Response Rates With 6-Week Combination Directly Acting Anti-Hepatitis C Virus Therapy in Patients With Advanced Liver Disease.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Feb 2016
Kattakuzhy Sarah, Wilson Eleanor, Sidharthan Sreetha, Sims Zayani, McLaughlin Mary, Price Angie, Silk Rachel, Gross Chloe, Akoth Elizabeth, McManus Maryellen, Emmanuel Benjamin, Shrivastava Shikha, Tang Lydia, Nelson Amy, Teferi Gebeyehu, Chavez Jose, Lam Brian, Mo Hongmei, Osinusi Anuoluwapo, Polis Michael A, Masur Henry, Kohli Anita, Kottilil Shyamasundaran
Abstract excerpt
BACKGROUND: Treatment of genotype 1 hepatitis C virus (HCV) infection with combination directly acting antivirals (DAA) for 8-24 weeks is associated with high rates of sustained virologic response (SVR). We previously demonstrated that adding a third DAA to ledipasvir and sofosbuvir (LDV/SOF) can result in high SVR rates in patients without cirrhosis. In this study, we investigated whether a similar regimen would...
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