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Article

The N-terminal pre-A region of Mycobacterium tuberculosis 2/2HbN promotes NO-dioxygenase activity.

The FEBS journal - 1 Jan 2016

Pesce Alessandra, Bustamante Juan P, Bidon-Chanal Axel, Boechi Leonardo, Estrin Darío A, Luque Francisco Javier, Sebilo Anne, Guertin Michel, Bolognesi Martino, Ascenzi Paolo, Nardini Marco

Abstract excerpt

UNLABELLED: A unique defense mechanisms by which Mycobacterium tuberculosis protects itself from nitrosative stress is based on the O2 -dependent NO-dioxygenase (NOD) activity of truncated hemoglobin 2/2HbN (Mt2/2HbN). The NOD activity largely depends on the efficiency of ligand migration to the heme cavity through a two-tunnel (long and short) system; recently, it was also correlated with the presence at the...

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Identifiers

PMID: 26499089
DOI: 10.1111/febs.13571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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