LIS1-associated classic lissencephaly: A retrospective, multicenter survey of the epileptogenic phenotype and response to antiepileptic drugs.

doi:10.1016/j.braindev.2015.10.001

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Article

LIS1-associated classic lissencephaly: A retrospective, multicenter survey of the epileptogenic phenotype and response to antiepileptic drugs.

Brain & development - 1 Apr 2016

Herbst Saskia M, Proepper Christiane R, Geis Tobias, Borggraefe Ingo, Hahn Andreas, Debus Otfried, Haeussler Martin, von Gersdorff Gero, Kurlemann Gerhard, Ensslen Matthias, Beaud Nathalie, Budde Joerg, Gilbert Michael, Heiming Ralf, Morgner Rita, Philippi Heike, Ross Sophia, Strobl-Wildemann Gertrud, Muelleder Kerstin, Vosschulte Paul, Morris-Rosendahl Deborah J, Schuierer Gerhard, Hehr Ute

Abstract excerpt

BACKGROUND: Patients with LIS1-associated classic lissencephaly typically present with severe psychomotor retardation and drug-resistant epilepsy within the first year. AIM: To analyze the epileptogenic phenotype and response to antiepileptic therapy in LIS1-associated classic lissencephaly. METHOD: Retrospective evaluation of 22 patients (8 months-24 years) with genetically and radiologically confirmed...

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PMID: 26494205
DOI: 10.1016/j.braindev.2015.10.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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