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Article

LIS1 missense mutations cause milder lissencephaly phenotypes including a child with normal IQ.

Neurology - 14 Aug 2001

Leventer R J, Cardoso C, Ledbetter D H, Dobyns W B

Abstract excerpt

BACKGROUND: Classical lissencephaly is a disorder of neuroblast migration with most patients having mutations of either the LIS1 or DCX genes. Most patients with lissencephaly secondary to LIS1 mutations have a severe malformation consisting of generalized agyria and pachygyria. However, increasing experience suggests that the phenotypic spectrum is wider than previously thought. METHODS: The authors describe the...

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Source

Identifiers

PMID: 11502906
DOI: 10.1212/wnl.57.3.416

Genes

DCX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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LIS1 missense mutations cause milder lissencephaly phenotypes including a child with normal IQ.PMID 11502906Read ↗

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