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Article

When less is more: primary immunodeficiency with an autoinflammatory kick.

Current opinion in allergy and clinical immunology - 1 Dec 2014

Giannelou Angeliki, Zhou Qing, Kastner Daniel L

Abstract excerpt

PURPOSE OF REVIEW: Next-generation sequencing is revolutionizing the molecular taxonomy of human disease. Recent studies of patients with unexplained autoinflammatory disorders reveal germline genetic mutations that target important regulators of innate immunity. RECENT FINDINGS: Whole-exome analyses of previously undiagnosed patients have catalyzed the recognition of two new disease genes. First, a phenotypic...

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Identifiers

PMID: 25337682
DOI: 10.1097/ACI.0000000000000117
PMCID: PMC4212813

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