Article
A peculiar VNTR in the cystathionine β-synthase gene is a risk factor for Down Syndrome.
Cellular and molecular biology (Noisy-le-Grand, France) - 16 Oct 2015
Salemi M, Barone C, Romano C, Salluzzo M G, Giambirtone M, Morale M C, Calogero A E, Grillo L, Bosco P, Romano C
Abstract excerpt
In the present study, we analysed a 31bp variable number of tandem repeats (VNTR) of the cystathionine ß-synthase (CBS) gene in 427 subjects: 127 patients with Down syndrome (DS) and in 60 of their mothers; 172 age-and sex-matched controls and in 68 of their mothers. A significant statistical difference in the distribution of the 21 repeat allele was found comparing mothers of subjects with DS versus mothers of...
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