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Article

The Effects of CFTR and Mucoid Phenotype on Susceptibility and Innate Immune Responses in a Mouse Model of Pneumococcal Lung Disease.

PloS one - 1 Jan 2015

Dennis Evida A, Coats Mamie T, Griffin Sarah E, Hale Joanetha Y, Novak Lea, Briles David E, Crain Marilyn J

Abstract excerpt

Recent studies have reported the isolation of highly mucoid serotype 3 Streptococcus pneumoniae (Sp) from the respiratory tracts of children with cystic fibrosis (CF). Whether these highly mucoid Sp contribute to, or are associated with, respiratory failure among patients with CF remains unknown. Other mucoid bacteria, predominately Pseudomonas aeruginosa, are associated with CF respiratory decline. We used a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cystic Fibrosis Transmembrane Conductance Regulator

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Source

Open in PubMed Open full text

Identifiers

PMID: 26469863
DOI: 10.1371/journal.pone.0140335
PMCID: PMC4607445

Genes

CFTR
CXCL1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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