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Article

Overall survival benefits of first-line EGFR tyrosine kinase inhibitors in EGFR-mutated non-small-cell lung cancers: a systematic review and meta-analysis.

British journal of cancer - 17 Nov 2015

Kuan Feng-Che, Kuo Liang-Tseng, Chen Min-Chi, Yang Cheng-Ta, Shi Chung-Sheng, Teng David, Lee Kuan-Der

Abstract excerpt

BACKGROUND: Accumulating data shows that exon 19 deletions and L858R, both activating epidermal growth factor receptor mutations in non-small-cell lung cancers (NSCLCs), are just two different entities in terms of prognosis and treatment response to tyrosine kinase inhibitors (TKIs). METHODS: A systematic review and meta-analysis of randomized controlled trials comparing TKIs with conventional chemotherapy was...

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Source

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Identifiers

PMID: 26461059
DOI: 10.1038/bjc.2015.356
PMCID: PMC4815883

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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