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Article

Integrated ordination of miRNA and mRNA expression profiles

12 Oct 2015

Abstract excerpt

BACKGROUND: Several studies have investigated miRNA and mRNA co-expression to identify regulatory networks at the transcriptional level. A typical finding of these studies is the presence of both negative and positive miRNA-mRNA correlations. Negative correlations are consistent with the expected, faster degradation of target mRNAs, whereas positive correlations denote the existence of feed-forward regulations...

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PMID: 26459852
DOI: 10.1186/s12864-015-1971-9

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