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Article

DDX3Y gene rescue of a Y chromosome AZFa deletion restores germ cell formation and transcriptional programs

12 Oct 2015

Abstract excerpt

Deletions of the AZFa region (AZoospermia Factor-a) region of the human Y chromosome cause irreversible spermatogenic failure that presents clinically in men as Sertoli-cell only (SCO) pathology of the testis. Deletions of the AZFa region typically encompass two genes: DDX3Y and USP9Y. However, human genetic evidence indicates that SCO is most tightly linked to deletion of DDX3Y and that deletions/mutations of...

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PMID: 26456624
DOI: 10.1038/srep15041

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DDX3Y gene rescue of a Y chromosome AZFa deletion restores germ cell formation and transcriptional programsPMID 26456624Read ↗

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