Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human G109E-inhibitor-1 impairs cardiac function and promotes arrhythmias.

Journal of molecular and cellular cardiology - 1 Dec 2015

Haghighi Kobra, Pritchard Tracy J, Liu Guan-Sheng, Singh Vivek P, Bidwell Philip, Lam Chi Keung, Vafiadaki Elizabeth, Das Parthib, Ma Jianyong, Kunduri Swati, Sanoudou Despina, Florea Stela, Vanderbilt Erica, Wang Hong-Shang, Rubinstein Jack, Hajjar Roger J, Kranias Evangelia G

Abstract excerpt

A hallmark of human and experimental heart failure is deficient sarcoplasmic reticulum (SR) Ca-uptake reflecting impaired contractile function. This is at least partially attributed to dephosphorylation of phospholamban by increased protein phosphatase 1 (PP1) activity. Indeed inhibition of PP1 by transgenic overexpression or gene-transfer of constitutively active inhibitor-1 improved Ca-cycling, preserved...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium-Calmodulin-Dependent Protein Kinase Type 2
Share to Calcium Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catecholamines

Share to Diastole

Share to Isoproterenol

Share to Myocardial Contraction

Share to Sarcoplasmic Reticulum

Share to Sodium-Calcium Exchanger

Source

Open in PubMed Open full text

Identifiers

PMID: 26455482
DOI: 10.1016/j.yjmcc.2015.10.004
PMCID: PMC4689614

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human G109E-inhibitor-1 impairs cardiac function and promotes arrhythmias.PMID 26455482Read ↗

CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome.Semantic proximity Read ↗

Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury.Semantic proximity Read ↗

A novel human R25C-phospholamban mutation is associated with super-inhibition of calcium cycling and ventricular arrhythmia.Semantic proximity Read ↗

A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.Semantic proximity Read ↗

Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure.Semantic proximity Read ↗

A novel, patient-derived RyR1 mutation impairs muscle function and calcium homeostasis in miceSemantic proximity Read ↗

Early consequences of the phospholamban mutation PLN-R14del+/- in a transgenic mouse model.Semantic proximity Read ↗

The phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unreponsive to standard heart failure therapy.Semantic proximity Read ↗

Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human.Semantic proximity Read ↗

Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and humanSemantic proximity Read ↗

Impaired calcium homeostasis is associated with sudden cardiac death and arrhythmias in a genetic equivalent mouse model of the human HRC-Ser96Ala variantSemantic proximity Read ↗

Phosphoinositide 3-kinase gamma: kinase-dependent and -independent activities in cardiovascular function and disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.