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Macrophage polarization in cattle experimentally exposed toMycobacterium aviumsubsp.paratuberculosis

9 Oct 2015

Abstract excerpt

Mycobacterium avium subspecies paratuberculosis (MAP), the causative agent of Johne's disease (JD) in cattle, has significant impacts on the livestock industry and has been implicated in the etiology of Crohn's disease. Macrophages play a key role in JD pathogenesis, which is driven by the manipulation of host immune mechanisms by MAP. A change in the macrophage microenvironment due to pathogenic or host-derived...

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PMID: 26454271
DOI: 10.1093/femspd/ftv085

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