Analysis of in vitro ADCC and clinical response to trastuzumab: possible relevance of FcγRIIIA/FcγRIIA gene polymorphisms and HER-2 expression levels on breast cancer cell lines.

doi:10.1186/s12967-015-0680-0

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Article

Analysis of in vitro ADCC and clinical response to trastuzumab: possible relevance of FcγRIIIA/FcγRIIA gene polymorphisms and HER-2 expression levels on breast cancer cell lines.

Journal of translational medicine - 8 Oct 2015

Boero Silvia, Morabito Anna, Banelli Barbara, Cardinali Barbara, Dozin Beatrice, Lunardi Gianluigi, Piccioli Patrizia, Lastraioli Sonia, Carosio Roberta, Salvi Sandra, Levaggi Alessia, Poggio Francesca, D'Alonzo Alessia, Romani Massimo, Del Mastro Lucia, Poggi Alessandro, Pistillo Maria Pia

Abstract excerpt

BACKGROUND: Trastuzumab is a humanized monoclonal antibody (mAb) currently used for the treatment of breast cancer (BC) patients with HER-2 overexpressing tumor subtype. Previous data reported the involvement of FcγRIIIA/IIA gene polymorphisms and/or antibody-dependent cellular cytotoxicity (ADCC) in the therapeutic efficacy of trastuzumab, although results on these issues are still controversial. This study was...

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PMID: 26450443
DOI: 10.1186/s12967-015-0680-0
PMCID: PMC4598965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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