Article
Porphyrin Binding to Gun4 Protein, Facilitated by a Flexible Loop, Controls Metabolite Flow through the Chlorophyll Biosynthetic Pathway.
The Journal of biological chemistry - 20 Nov 2015
Kopečná Jana, Cabeza de Vaca Israel, Adams Nathan B P, Davison Paul A, Brindley Amanda A, Hunter C Neil, Guallar Victor, Sobotka Roman
Abstract excerpt
In oxygenic phototrophs, chlorophylls, hemes, and bilins are synthesized by a common branched pathway. Given the phototoxic nature of tetrapyrroles, this pathway must be tightly regulated, and an important regulatory role is attributed to magnesium chelatase enzyme at the branching between the heme and chlorophyll pathway. Gun4 is a porphyrin-binding protein known to stimulate in vitro the magnesium chelatase...
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