Article
Whole genome sequence analysis reveals limited diversity among Clostridioides difficile ribotype 027 and 078 isolates collected in 22 hospitals in Berlin and Brandenburg, Germany.
Antimicrobial resistance and infection control - 28 May 2025
Dirks Esther E, Pfiffer Vanessa, Sohl Genevieve, Berger Fabian K, Friesen Ina, Friesen Johannes, Ignatius Ralf, Elias Johannes, Mellmann Alexander, Arvand Mardjan
Abstract excerpt
BACKGROUND: Clostridioides difficile infections (CDI) present significant health risks and are among the most important nosocomial infections. Ribotype (RT) 027 poses a particular risk due to its proposed "hypervirulence". Traditionally, C. difficile isolates are characterized using PCR-ribotyping. More recently, whole genome sequence (WGS) analysis is increasingly used, which may provide a higher discriminatory...
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