Sulfonylurea Therapy Benefits Neurological and Psychomotor Functions in Patients With Neonatal Diabetes Owing to Potassium Channel Mutations.

doi:10.2337/dc15-0837

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Sulfonylurea Therapy Benefits Neurological and Psychomotor Functions in Patients With Neonatal Diabetes Owing to Potassium Channel Mutations.

Diabetes care - 1 Nov 2015

Beltrand Jacques, Elie Caroline, Busiah Kanetee, Fournier Emmanuel, Boddaert Nathalie, Bahi-Buisson Nadia, Vera Miriam, Bui-Quoc Emmanuel, Ingster-Moati Isabelle, Berdugo Marianne, Simon Albane, Gozalo Claire, Djerada Zoubir, Flechtner Isabelle, Treluyer Jean-Marc, Scharfmann Raphael, Cavé Helene, Vaivre-Douret Laurence, Polak Michel

Abstract excerpt

OBJECTIVE: Neonatal diabetes secondary to mutations in potassium-channel subunits is a rare disease but constitutes a paradigm for personalized genetics-based medicine, as replacing the historical treatment with insulin injections with oral sulfonylurea (SU) therapy has been proven beneficial. SU receptors are widely expressed in the brain, and we therefore evaluated potential effects of SU on neurodevelopmental...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Administration, Oral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus

Share to Drug Substitution

Share to Glyburide

Share to Hypoglycemic Agents

Share to Potassium Channels, Inwardly Rectifying

Share to Psychomotor Performance

Share to Sulfonylurea Receptors

Source

Open in PubMed

Identifiers

PMID: 26438614
DOI: 10.2337/dc15-0837

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sulfonylurea Therapy Benefits Neurological and Psychomotor Functions in Patients With Neonatal Diabetes Owing to Potassium Channel Mutations.PMID 26438614Read ↗

Sulfonylurea for improving neurological features in neonatal diabetes: A systematic review and meta-analyses.Semantic proximity Read ↗

Emerging technologies in pediatrics: the paradigm of neonatal diabetes mellitus.Semantic proximity Read ↗

Neonatal Diabetes and the KATP Channel: From Mutation to Therapy.Semantic proximity Read ↗

Improved motor development and good long-term glycaemic control with sulfonylurea treatment in a patient with the syndrome of intermediate developmental delay, early-onset generalised epilepsy and neonatal diabetes associated with the V59M mutation in the KCNJ11 gene.Semantic proximity Read ↗

Neonatal Diabetes Caused by Activating Mutations in the Sulphonylurea ReceptorSemantic proximity Read ↗

Neonatal Diabetes Mellitus: An Update on Diagnosis and Management.Semantic proximity Read ↗

New uses for old drugs: neonatal diabetes and sulphonylureas.Semantic proximity Read ↗

Neuropsychological dysfunction and developmental defects associated with genetic changes in infants with neonatal diabetes mellitus: a prospective cohort study [corrected].Semantic proximity Read ↗

Update in neonatal diabetes.Semantic proximity Read ↗

Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study.Semantic proximity Read ↗

Detection of KCNJ11 gene mutations in a family with neonatal diabetes mellitus: implications for therapeutic management of family members with long-standing disease.Semantic proximity Read ↗

Neonatal diabetes due to potassium channel mutation: Response to sulfonylurea according to the genotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.