Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New uses for old drugs: neonatal diabetes and sulphonylureas.

Cell metabolism - 3 Mar 2010

Ashcroft Frances M

Abstract excerpt

The discovery that their neonatal diabetes is caused by gain-of-function mutations in the K(ATP) channel has enabled many patients to switch from insulin to oral sulphonylurea drugs. Here, I review molecular, physiological, and clinical features of this change in therapy.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Insulin
Share to Diabetes Mellitus
Share to Diabetes Mellitus, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infant, Newborn

Share to KATP Channels

Share to Mutation

Share to Sulfonylurea Compounds

Source

Identifiers

PMID: 20197050
DOI: 10.1016/j.cmet.2010.02.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New uses for old drugs: neonatal diabetes and sulphonylureas.PMID 20197050Read ↗

Neonatal Diabetes and the KATP Channel: From Mutation to Therapy.Semantic proximity Read ↗

Neonatal Diabetes Caused by Activating Mutations in the Sulphonylurea ReceptorSemantic proximity Read ↗

Mutations in the Kir6.2 subunit of the KATP channel and permanent neonatal diabetes: new insights and new treatment.Semantic proximity Read ↗

[Low doses of sulphonyluria as a successful replacement for insulin therapy in a patient with neonatal diabetes due to a mutation of KCNJ11 gene encoding Kir6.2].Semantic proximity Read ↗

Activating mutations in Kir6.2 and neonatal diabetes: new clinical syndromes, new scientific insights, and new therapy.Semantic proximity Read ↗

Emerging technologies in pediatrics: the paradigm of neonatal diabetes mellitus.Semantic proximity Read ↗

Neonatal diabetes.Semantic proximity Read ↗

Permanent neonatal diabetes by a new mutation in KCNJ11: unsuccessful switch to sulfonylurea.Semantic proximity Read ↗

Neonatal Diabetes Mellitus: An Update on Diagnosis and Management.Semantic proximity Read ↗

New insights into KATP channel gene mutations and neonatal diabetes mellitus.Semantic proximity Read ↗

[Permanent neonatal diabetes with known genetic background: oral drugs in treatment of childhood diabetes].Semantic proximity Read ↗

Neonatal diabetes: an expanding list of genes allows for improved diagnosis and treatment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.