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Article

Multiple Genetic Mutations Associated with Polymyxin Resistance in Acinetobacter baumannii.

Antimicrobial agents and chemotherapy - 1 Dec 2015

Lim Tze Peng, Ong Rick Twee-Hee, Hon Pei-Yun, Hawkey Jane, Holt Kathryn E, Koh Tse Hsien, Leong Micky Lo-Ngah, Teo Jocelyn Qi-Min, Tan Thean Yen, Ng Mary Mah-Lee, Hsu Li Yang

Abstract excerpt

We studied polymyxin B resistance in 10 pairs of clinical Acinetobacter baumannii isolates, two of which had developed polymyxin B resistance in vivo. All polymyxin B-resistant isolates had lower growth rates than and substitution mutations in the lpx or pmrB gene compared to their parent isolates. There were significant differences in terms of antibiotic susceptibility and genetic determinants of resistance in...

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Identifiers

PMID: 26438500
DOI: 10.1128/AAC.01884-15
PMCID: PMC4649193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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