No Evidence of Human Leukocyte Antigen Gene Association With Rheumatic Fever Among Children in Samoa.

Abstract excerpt

Human leukocyte antigens (HLAs) have been implicated in rheumatic fever pathogenesis. This pilot whole genome association study compares genotypes of Samoan children with rheumatic fever to unaffected siblings and unrelated healthy controls. No risk-related genotypes were associated with HLA genes. Thirteen Regions of Interest were identified as candidates for further study.

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