Article
Polymorphisms in Genes of Relevance for Oestrogen and Oxytocin Pathways and Risk of Barrett's Oesophagus and Oesophageal Adenocarcinoma: A Pooled Analysis from the BEACON Consortium.
PloS one - 1 Jan 2015
Lagergren Katarina, Ek Weronica E, Levine David, Chow Wong-Ho, Bernstein Leslie, Casson Alan G, Risch Harvey A, Shaheen Nicholas J, Bird Nigel C, Reid Brian J, Corley Douglas A, Hardie Laura J, Wu Anna H, Fitzgerald Rebecca C, Pharoah Paul, Caldas Carlos, Romero Yvonne, Vaughan Thomas L, MacGregor Stuart, Whiteman David, Westberg Lars, Nyren Olof, Lagergren Jesper
Abstract excerpt
BACKGROUND: The strong male predominance in oesophageal adenocarcinoma (OAC) and Barrett's oesophagus (BO) continues to puzzle. Hormonal influence, e.g. oestrogen or oxytocin, might contribute. METHODS: This genetic-epidemiological study pooled 14 studies from three continents, Australia, Europe, and North America. Polymorphisms in 3 key genes coding for the oestrogen pathway (receptor alpha (ESR1), receptor beta...
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