Article
Association of oestrogen-receptor gene (ESR1) polymorphisms with migraine in the large Norfolk Island pedigree.
Cephalalgia : an international journal of headache - 1 Oct 2013
Rodriguez-Acevedo Astrid J, Maher Bridget H, Lea Rodney A, Benton Miles, Griffiths Lyn R
Abstract excerpt
BACKGROUND: Oestrogen receptor 1 ( ESR1) is located in region 6q25.1 and encodes a ligand-activated transcription factor composed of several domains important for hormone binding and transcription activation. Progesterone receptor ( PGR) is located in 11q22-23 and mediates the role of progesterone interacting with different transcriptional co-regulators. ESR1 and PGR have previously been implicated in migraine...
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