Article
Challenges and opportunities of next-generation sequencing: a cytopathologist's perspective.
Cytopathology : official journal of the British Society for Clinical Cytology - 1 Oct 2015
Vigliar E, Malapelle U, de Luca C, Bellevicine C, Troncone G
Abstract excerpt
Molecular cytopathology has gene sequencing as its core technology. Until recently, cytological samples were only tested by sequential single-gene mutational tests. Today, with the better understanding of the molecular events involved in malignancy and the mechanisms of pharmacotherapy, larger gene panels are more informative than a single biomarker. Next-generation sequencing (NGS), matched with the multiplex...
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