Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Performance of In Silico Tools for the Evaluation of UGT1A1 Missense Variants.

Human mutation - 1 Dec 2015

Rodrigues Carina, Santos-Silva Alice, Costa Elísio, Bronze-da-Rocha Elsa

Abstract excerpt

Variations in the gene encoding uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) are particularly important because they have been associated with hyperbilirubinemia in Gilbert's and Crigler-Najjar syndromes as well as with changes in drug metabolism. Several variants associated with these phenotypes are nonsynonymous single-nucleotide polymorphisms (nsSNPs). Bioinformatics approaches have gained...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Computational Biology
Share to Databases, Nucleic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Glucuronosyltransferase

Share to Mutation, Missense

Share to Software

Share to Web Browser

Source

Identifiers

PMID: 26377032
DOI: 10.1002/humu.22903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Performance of In Silico Tools for the Evaluation of UGT1A1 Missense Variants.PMID 26377032Read ↗

Prediction of deleterious non-synonymous single-nucleotide polymorphisms of human uridine diphosphate glucuronosyltransferase genes.Semantic proximity Read ↗

A Comprehensive In Silico Analysis of the Functional and Structural Impact of Nonsynonymous SNPs in the ABCA1 Transporter GeneSemantic proximity Read ↗

Benchmarking analysis of deleterious SNP prediction tools on CYP2D6 enzymeSemantic proximity Read ↗

Benchmarking Computational Methods for Estimating the Pathogenicity of Wilson’s Disease MutationsSemantic proximity Read ↗

Computing the Pathogenicity of Wilson's Disease ATP7B Mutations: Implications for Disease Prevalence.Semantic proximity Read ↗

Prediction of the pathogenicity of antithrombin sequence variations by in silico methods.Semantic proximity Read ↗

Accurate prediction of the functional significance of single nucleotide polymorphisms and mutations in the ABCA1 gene.Semantic proximity Read ↗

Genetic lesions in the UGT1A1 genes among Gilbert's syndrome patients from India.Semantic proximity Read ↗

Crigler-Najjar syndrome in The Netherlands: identification of four novel UGT1A1 alleles, genotype-phenotype correlation, and functional analysis of 10 missense mutants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.