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Article

Coordination of self-renewal in glioblastoma by integration of adhesion and microRNA signaling

15 Sept 2015

Abstract excerpt

BACKGROUND: Cancer stem cells (CSCs) provide an additional layer of complexity for tumor models and targets for therapeutic development. The balance between CSC self-renewal and differentiation is driven by niche components including adhesion, which is a hallmark of stemness. While studies have demonstrated that the reduction of adhesion molecules, such as integrins and junctional adhesion molecule-A (JAM-A),...

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PMID: 26374689
DOI: 10.1093/neuonc/nov196

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