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Article

Overexpression of MYB drives proliferation of CYLD-defective cylindroma cells.

The Journal of pathology - 1 Jun 2016

Rajan Neil, Andersson Mattias K, Sinclair Naomi, Fehr André, Hodgson Kirsty, Lord Christopher J, Kazakov Dmitry V, Vanecek Tomas, Ashworth Alan, Stenman Göran

Abstract excerpt

Cutaneous cylindroma is an adnexal tumour with apocrine differentiation. A predisposition to multiple cylindromas is seen in patients with Brooke-Spiegler syndrome, who carry germline mutations in the tumour suppressor gene CYLD. Previous studies of inherited cylindromas have highlighted the frequent presence of bi-allelic truncating CYLD mutations as a recurrent driver mutation. We have previously shown that...

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Topics

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Share to Deubiquitinating Enzyme CYLD
Share to Germ-Line Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization, Fluorescence

Share to Neoplastic Syndromes, Hereditary

Share to Oligonucleotide Array Sequence Analysis

Share to Oncogene Proteins, Fusion

Share to Skin Neoplasms

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 26969893
DOI: 10.1002/path.4717
PMCID: PMC4869681

Genes

MYB
CYLD
NFIB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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Overexpression of MYB drives proliferation of CYLD-defective cylindroma cells.PMID 26969893Read ↗

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