Article
Outcome in patients treated with isolated liver transplantation for familial transthyretin amyloidosis to prevent cardiomyopathy.
Clinical transplantation - 1 Dec 2015
Nelson Laerke M, Penninga Luit, Villadsen Gerda E, Mølgaard Henning, Eiskjaer Hans, Hillingsø Jens G, Rasmussen Allan
Abstract excerpt
BACKGROUND: Familial transthyretin (TTR) amyloidosis is caused by different TTR mutations resulting in different clinical phenotypes of the disease. The Leu111Met mutation causes severe restrictive cardiomyopathy. Liver transplantation (LTx) is an established treatment option for patients with TTR amyloidosis; however, information on outcome after isolated LTx in patients with Leu111Met mutation amyloidosis is...
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