Article
Meningococcal Antigen Typing System Development and Application to the Evaluation of Effectiveness of Meningococcal B Vaccine and Possible Use for Other Purposes.
Journal of immunology research - 1 Jan 2015
Domnich Alexander, Gasparini Roberto, Amicizia Daniela, Boccadifuoco Giuseppe, Giuliani Marzia Monica, Panatto Donatella
Abstract excerpt
Development of the 4-component meningococcal serogroup B vaccine (4CMenB) has required new assays for the reliable evaluation of the expression and cross-reactivity of those specific antigen variants that are predicted to be targeted by bactericidal antibodies elicited by the vaccine in different isolates. Existing laboratory techniques, such as multilocus sequence typing, are poorly suited to this purpose, since...
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