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Article

Screening key genes associated with congenital heart defects in Down syndrome based on differential expression network.

International journal of clinical and experimental pathology - 1 Jan 2015

Yu Shan, Yi Huani, Wang Zhimin, Dong Juan

Abstract excerpt

BACKGROUND: Down syndrome (DS) is the most common viable chromosomal disorder with intellectual impairment and several other developmental abnormalities. Forty to fifty percent of newborns with DS have some form of congenital heart defects (CHD). The genome of CHD in DS has already been obtained, but the underlying genomic or gene expression variation that contributes to the manifestation of a CHD in DS is still...

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Identifiers

PMID: 26339408
PMCID: PMC4555736

Genes

APP
HUWE1
SRC
UBC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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