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MicroRNA-34a inhibits human trophoblast cell invasion by targeting MYC

2 Sept 2015

Abstract excerpt

BACKGROUND: Preeclampsia, one of the major disorders of pregnancy, is characterized by inadequate trophoblast invasion and defective trophoblast-mediated remodeling of placental vasculature. MicroRNA-34a (miR-34a) has been found to be aberrantly expressed in the placentas of preeclamptic patients, yet its role in placental development and in the pathogenesis of preeclampsia remains elusive. RESULTS: The levels of...

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PMID: 26335888
DOI: 10.1186/s12860-015-0068-2

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