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Article

Irisin and the Metabolic Phenotype of Adults with Prader-Willi Syndrome.

PloS one - 1 Jan 2015

Hirsch Harry J, Gross Itai, Pollak Yehuda, Eldar-Geva Talia, Gross-Tsur Varda

Abstract excerpt

CONTEXT: Hyperphagia, low resting energy expenditure, and abnormal body composition contribute to severe obesity in Prader Willi syndrome (PWS). Irisin, a circulating myokine, stimulates "browning" of white adipose tissue resulting in increased energy expenditure and improved insulin sensitivity. Irisin has not been previously studied in PWS. OBJECTIVES: Compare plasma and salivary irisin in PWS adults and normal...

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Identifiers

PMID: 26334732
DOI: 10.1371/journal.pone.0136864
PMCID: PMC4559418

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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