Toward an orofacial gene regulatory network

Abstract excerpt

Orofacial clefting is a common birth defect with significant morbidity. A panoply of candidate genes have been discovered through synergy of animal models and human genetics. Among these, variants in interferon regulatory factor 6 (IRF6) cause syndromic orofacial clefting and contribute risk toward isolated cleft lip and palate (1/700 live births). Rare variants in IRF6 can lead to Van der Woude syndrome...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cleft Lip and Palate Research
• Share to Craniofacial Disorders and Treatments
• Share to Head and Neck Surgical Oncology