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Article

Telomerase Inhibitor Imetelstat in Patients with Essential Thrombocythemia.

The New England journal of medicine - 3 Sept 2015

Baerlocher Gabriela M, Oppliger Leibundgut Elisabeth, Ottmann Oliver G, Spitzer Gary, Odenike Olatoyosi, McDevitt Michael A, Röth Alexander, Daskalakis Michael, Burington Bart, Stuart Monic, Snyder David S

Abstract excerpt

BACKGROUND: Imetelstat, a 13-mer oligonucleotide that is covalently modified with lipid extensions, competitively inhibits telomerase enzymatic activity. It has been shown to inhibit megakaryocytic proliferation in vitro in cells obtained from patients with essential thrombocythemia. In this phase 2 study, we investigated whether imetelstat could elicit hematologic and molecular responses in patients with...

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Source

Identifiers

PMID: 26332546
DOI: 10.1056/NEJMoa1503479

Genes

CALR
JAK2
MPL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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