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Article

MicroRNAs involvement in fludarabine refractory chronic lymphocytic leukemia

26 May 2010

Abstract excerpt

BACKGROUND: Fludarabine, is one of the most active single agents in the treatment of chronic lymphocytic leukemia (CLL). Over time, however, virtually all CLL patients become fludarabine-refractory. To elucidate whether microRNAs are involved in the development of fludarabine resistance, we analyzed the expression of 723 human miRNAs before and 5-days after fludarabine mono-therapy in 17 CLL patients which were...

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PMID: 20504344
DOI: 10.1186/1476-4598-9-123

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