Efficacy and safety of ombitasvir/paritaprevir/r and dasabuvir compared to IFN-containing regimens in genotype 1 HCV patients: The MALACHITE-I/II trials.

doi:10.1016/j.jhep.2015.08.015

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Article

Efficacy and safety of ombitasvir/paritaprevir/r and dasabuvir compared to IFN-containing regimens in genotype 1 HCV patients: The MALACHITE-I/II trials.

Journal of hepatology - 1 Jan 2016

Dore Gregory J, Conway Brian, Luo Yan, Janczewska Ewa, Knysz Brygida, Liu Yan, Streinu-Cercel Adrian, Caruntu Florin Alexandru, Curescu Manuela, Skoien Richard, Ghesquiere Wayne, Mazur Włodzimierz, Soza Alejandro, Fuster Francisco, Greenbloom Susan, Motoc Adriana, Arama Victoria, Shaw David, Tornai Istvan, Sasadeusz Joseph, Dalgard Olav, Sullivan Danielle, Liu Xuan, Kapoor Mudra, Campbell Andrew, Podsadecki Thomas

Abstract excerpt

BACKGROUND & AIMS: Telaprevir plus pegylated interferon/ribavirin (TPV+PegIFN/RBV) remains a therapeutic option for chronic hepatitis C virus (HCV) genotype (GT) 1 infection in many regions. We conducted two open-label, phase IIIb trials comparing safety and efficacy of all-oral ombitasvir/paritaprevir/ritonavir and dasabuvir±ribavirin (OBV/PTV/r+DSV±RBV) and TPV+PegIFN/RBV. METHODS: Treatment-naïve (MALACHITE-I)...

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PMID: 26321288
DOI: 10.1016/j.jhep.2015.08.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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