Non-synonymous FGD3 Variant as Positional Candidate for Disproportional Tall Stature Accounting for a Carcass Weight QTL (CW-3) and Skeletal Dysplasia in Japanese Black Cattle.

doi:10.1371/journal.pgen.1005433

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Article

Non-synonymous FGD3 Variant as Positional Candidate for Disproportional Tall Stature Accounting for a Carcass Weight QTL (CW-3) and Skeletal Dysplasia in Japanese Black Cattle.

PLoS genetics - 1 Aug 2015

Takasuga Akiko, Sato Kunio, Nakamura Ryouichi, Saito Yosuke, Sasaki Shinji, Tsuji Takehito, Suzuki Akio, Kobayashi Hiroshi, Matsuhashi Tamako, Setoguchi Koji, Okabe Hiroshi, Ootsubo Toshitake, Tabuchi Ichiro, Fujita Tatsuo, Watanabe Naoto, Hirano Takashi, Nishimura Shota, Watanabe Toshio, Hayakawa Makio, Sugimoto Yoshikazu, Kojima Takatoshi

Abstract excerpt

Recessive skeletal dysplasia, characterized by joint- and/or hip bone-enlargement, was mapped within the critical region for a major quantitative trait locus (QTL) influencing carcass weight; previously named CW-3 in Japanese Black cattle. The risk allele was on the same chromosome as the Q allele that increases carcass weight. Phenotypic characterization revealed that the risk allele causes disproportional tall...

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PMID: 26306008
DOI: 10.1371/journal.pgen.1005433
PMCID: PMC4549114

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FGD3

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