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Article

Simeprevir and sofosbuvir for treatment of hepatitis C infection.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists - 1 Sept 2015

Chopp Shelby, Vanderwall Rebecca, Hult Amanda, Klepser Michael

Abstract excerpt

PURPOSE: The pharmacology, pharmacokinetics, efficacy, safety, costs, and place in therapy of simeprevir and sofosbuvir in the management of hepatitis C virus (HCV) infection are reviewed. SUMMARY: Sofosbuvir and simeprevir are classified as direct-acting agents because they target specific proteins essential to the replication of HCV. Phase III trials demonstrated that simeprevir in combination with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26294237
DOI: 10.2146/ajhp140290

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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