Copy number variation in exportin-4 (XPO4) gene and its association with histological severity of non-alcoholic fatty liver disease.

doi:10.1038/srep13306

Article

Copy number variation in exportin-4 (XPO4) gene and its association with histological severity of non-alcoholic fatty liver disease.

Scientific reports - 21 Aug 2015

Zain Shamsul Mohd, Mohamed Zahurin, Pirmohamed Munir, Tan Hwa Li, Alshawsh Mohammed Abdullah, Mahadeva Sanjiv, Chan Wah-Kheong, Mustapha Nik Raihan Nik, Mohamed Rosmawati

Abstract excerpt

A recent genome-wide copy number (CNV) scan identified a 13q12.11 duplication in the exportin-4 (XPO4) gene to be associated with non-alcoholic steatohepatitis (NASH). We sought to confirm the finding in a larger cohort and to assess the serum XPO4 pattern in a broad spectrum of non-alcoholic fatty liver disease (NAFLD) cases. We analysed 249 NAFLD patients and 232 matched controls using TaqMan assay and serum...

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Copy number variation in exportin-4 (XPO4) gene and its association with histological severity of non-alcoholic fatty liver disease.

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