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The Reemergent 1977 H1N1 Strain and the Gain-of-Function Debate

19 Aug 2015

Abstract excerpt

The 1977-1978 influenza epidemic was probably not a natural event, as the genetic sequence of the virus was nearly identical to the sequences of decades-old strains. While there are several hypotheses that could explain its origin, the possibility that the 1977 epidemic resulted from a laboratory accident has recently gained popularity in discussions about the biosafety risks of gain-of-function (GOF) influenza...

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PMID: 26286690
DOI: 10.1128/mbio.01013-15

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