Article
Restrictive IgG antibody response against mutated citrullinated vimentin predicts response to rituximab in patients with rheumatoid arthritis.
Arthritis research & therapy - 13 Aug 2015
Lindenberg Luisa, Spengler Lydia, Bang Holger, Dorner Thomas, Maslyanskiy Aleksej L, Lapin Sergey V, Ilivanova Elena I, Martinez-Gamboa Lorena, Bastian Hans, Wittenborn Esther, Egerer Karl, Burmester Gerd-R, Feist Eugen
Abstract excerpt
INTRODUCTION: Antibodies against mutated citrullinated vimentin (AMCV) represent a useful diagnostic marker with correlation to disease activity in patients with rheumatoid arthritis (RA). Since seropositivity for citrullinated autoantibodies was predictive for response to B-cell depleting therapy (BCDT) with rituximab (RTX), we investigated whether differences in antibody fine reactivity and immunoglobulin (Ig)...
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