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Article

Peripheral Blood Mononuclear Cells Enhance Cartilage Repair in in vivo Osteochondral Defect Model.

PloS one - 1 Jan 2015

Hopper Niina, Wardale John, Brooks Roger, Power Jonathan, Rushton Neil, Henson Frances

Abstract excerpt

This study characterized peripheral blood mononuclear cells (PBMC) in terms of their potential in cartilage repair and investigated their ability to improve the healing in a pre-clinical large animal model. Human PBMCs were isolated with gradient centrifugation and adherent PBMC's were evaluated for their ability to differentiate into adipogenic, chondrogenic and osteogenic lineages and also for their expression...

Read the complete abstract on PubMed

Topics

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Share to Cartilage
Share to Cell Differentiation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cellular Microenvironment

Share to Leukocytes, Mononuclear

Share to Wound Healing

Source

Open in PubMed Open full text

Identifiers

PMID: 26252391
DOI: 10.1371/journal.pone.0133937
PMCID: PMC4529143

Genes

MSC
BMP2
BMP6
GDF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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