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Article

Cone and rod loss in Stargardt disease revealed by adaptive optics scanning light ophthalmoscopy.

JAMA ophthalmology - 1 Oct 2015

Song Hongxin, Rossi Ethan A, Latchney Lisa, Bessette Angela, Stone Edwin, Hunter Jennifer J, Williams David R, Chung Mina

Abstract excerpt

IMPORTANCE: Stargardt disease (STGD1) is characterized by macular atrophy and flecks in the retinal pigment epithelium. The causative ABCA4 gene encodes a protein localizing to photoreceptor outer segments. The pathologic steps by which ABCA4 mutations lead to clinically detectable retinal pigment epithelium changes remain unclear. We investigated early STGD1 using adaptive optics scanning light ophthalmoscopy....

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Share to ATP-Binding Cassette Transporters
Share to Macular Degeneration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ophthalmoscopy

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Share to Photoreceptor Cells, Vertebrate

Share to Stargardt Disease

Share to Tomography, Optical Coherence

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Source

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Identifiers

PMID: 26247787
DOI: 10.1001/jamaophthalmol.2015.2443
PMCID: PMC4600048

Genes

ABCA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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