Article
Species-wide whole genome sequencing reveals historical global spread and recent local persistence in Shigella flexneri.
eLife - 4 Aug 2015
Connor Thomas R, Barker Clare R, Baker Kate S, Weill François-Xavier, Talukder Kaisar Ali, Smith Anthony M, Baker Stephen, Gouali Malika, Pham Thanh Duy, Jahan Azmi Ishrat, Dias da Silveira Wanderley, Semmler Torsten, Wieler Lothar H, Jenkins Claire, Cravioto Alejandro, Faruque Shah M, Parkhill Julian, Wook Kim Dong, Keddy Karen H, Thomson Nicholas R
Abstract excerpt
Shigella flexneri is the most common cause of bacterial dysentery in low-income countries. Despite this, S. flexneri remains largely unexplored from a genomic standpoint and is still described using a vocabulary based on serotyping reactions developed over half-a-century ago. Here we combine whole genome sequencing with geographical and temporal data to examine the natural history of the species. Our analysis...
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