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Article

Determined to Fail--the Role of Genetic Mechanisms in Heart Failure.

Current heart failure reports - 1 Oct 2015

Kayvanpour Elham, Katus Hugo A, Meder Benjamin

Abstract excerpt

Genetic variants contribute to several steps during heart failure pathophysiology. The mechanisms include frequent polymorphisms that increase the susceptibility to heart failure in the general population and rare variants as causes of an underlying cardiomyopathy. In this review, we highlight recent discoveries made by genetic approaches and provide an outlook onto the role of epigenetic modifiers of heart failure.

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Share to Cardiomyopathy, Dilated
Share to Epigenesis, Genetic
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Failure

Share to Polymorphism, Single Nucleotide

Share to Renin-Angiotensin System

Source

Identifiers

PMID: 26233853
DOI: 10.1007/s11897-015-0264-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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