Article
Towards a comprehensive picture of alloacceptor tRNA remolding in metazoan mitochondrial genomes.
Nucleic acids research - 18 Sept 2015
Sahyoun Abdullah H, Hölzer Martin, Jühling Frank, Höner zu Siederdissen Christian, Al-Arab Marwa, Tout Kifah, Marz Manja, Middendorf Martin, Stadler Peter F, Bernt Matthias
Abstract excerpt
Remolding of tRNAs is a well-documented process in mitochondrial genomes that changes the identity of a tRNA. It involves a duplication of a tRNA gene, a mutation that changes the anticodon and the loss of the ancestral tRNA gene. The net effect is a functional tRNA that is more closely related to tRNAs of a different alloacceptor family than to tRNAs with the same anticodon in related species. Beyond being of...
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