Article
Prenatal ethanol exposure induces the osteoarthritis-like phenotype in female adult offspring rats with a post-weaning high-fat diet and its intrauterine programming mechanisms of cholesterol metabolism.
Toxicology letters - 14 Oct 2015
Ni Qubo, Wang Linlong, Wu Yunpeng, Shen Lang, Qin Jun, Liu Yansong, Magdalou Jacques, Chen Liaobin, Wang Hui
Abstract excerpt
Osteoarthritis (OA) development is associated with hypercholesterolemia in adults. Our previous study demonstrated that offspring with intrauterine growth retardation (IUGR) due to prenatal ethanol exposure (PEE) had a high risk of developing hypercholesterolemia and metabolic syndrome when fed a post-weaning high-fat diet (HFD). In this study, we examined the changes in articular chondrocytes of IUGR offspring...
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